I have a PhD in Biochemistry, with a focus on the biochemical and structural characterisation of proteins that replicate DNA through damage caused by mutagens such as UV light.
I worked in the laboratory of Prof. Aidan Doherty at the Genome Damage and Stability Centre and have a number of high-impact publications as detailed below.
Molecular dissection of the domain architecture and catalytic activities of human PrimPol.
Nucleic Acids Research. 2014. 42(9):5830-45
Keen BA, Jozwiakowski SK, Bailey LJ, Bianchi J, Doherty AJ.
Human PrimPol mutation associated with high myopia has a DNA replication defect.
Nucleic Acids Research. 2014. 42(19):12102-11
Keen BA, Bailey LJ, Jozwiakowski SK, Doherty AJ.
Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes.
Nucleic Acids Research. 2015. 43(14):6651-64
Guilliam TA, Keen BA, Brissett NC, Doherty AJ.
Molecular basis for PrimPol recruitment to replication forks by RPA.
Nature Communications. 2017. 15222.
Guilliam TA, Brissett NC, Ehlinger A, Keen BA, Kolesar P, Taylor EM, Bailey LJ, Lindsay HD, Chazin WJ, Doherty AJ.
Additionally, I have a first-class honours degree from the University of Southampton in Biochemistry